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Phase I-II Clinical Study of Taurine for External Use in the Prevention and Treatment of Acute Radiation Skin Injury

RecruitingPhase 1, Phase 2Ages 18 Years - anyFemaleShandong Cancer Hospital and Institute
NCT06847555 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Acute radiation skin injury is the most common side effect of radiation therapy in patients with chest tumors, which can be manifested as erythema, dry peeling, wet peeling, and severe ulcers. Even with current advanced radiotherapy techniques, such as intensity-modulated reverse radiation therapy (IMRT), about one-third of patients develop grade 2 or higher skin damage during radiotherapy. Radiation skin damage can cause discomfort to patients, thus affecting their daily life and reducing their quality of life. In severe cases, it can even reduce the efficacy due to prolonged treatment time. Therefore, prevention and treatment of acute radiation skin injury is a difficult problem to be solved urgently in clinical practice. Even with current advanced radiotherapy techniques, such as intensity-modulated reverse radiation therapy (IMRT), about one-third of patients develop grade 2 or hig

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📋 Eligibility rules (as published)
Inclusion Criteria: * Breast cancer patients scheduled for conventional fractionated adjuvant * radiotherapy. * 18 years or older * ECOG score 0-1 * No previous history of other neoplasms. * No previous chest radiotherapy. * Heart, lung function, liver function and kidney function were within normal range. * Voluntary informed consent. Exclusion Criteria: * Pregnant or lactating women, women in childbearing years who do not use effective contraception； * Patients with mental disease or nervous system disease, unable to clearly describe treatment response (such as cerebrovascular accident sequela); * Those who have serious heart, liver, kidney and other organ diseases or diabetes and are not expected to complete the treatment plan; * serious, uncontrolled diseases and infections; * Pregnant or lactating patients. * Allergic to taurine and any of its components. * Has participated in other clinical trials. * knot tissue disease * active hepatitis * Obvious diseases that the investigator considers should be excluded from this study
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What it tests

  • Radiation
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Where

1 site
Shandong Cancer Hospital
Jinan, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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