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Effect of Intralesional Injection of Corticosteroids Combined with Hyaluronidase in Treatment of Minimal Associated Pathological Lesions of Vocal Folds, Participants and Condition: Patients with Benign Vocal Fold Lesions, Intervention: Intralesional Injection Via Working Channel of Nasofiberscope

RecruitingEARLY Phase 1Ages 18 Years - 60 YearsAllMansoura University
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In plain words

What the trial is, and whether it could suit you

Voice disorders encompass a wide range of pathologies that result in various degrees of voice impairment and decreased quality of life, Minimal Associated Pathological Lesions (MAPLs), include a group of non-malignant growths on the vocal folds like vocal fold nodules, polyps, papilloma, Reinke's oedema, polypoidal degeneration and cysts, The pathophysiology of MAPLs include abnormal inflammatory response to local trauma. Histologically, the superficial layer of the lamina propria shows oedema, fibrosis, fibrin and hemosiderin deposit, interstitial haemorrhage and inflammatory cell infiltration, Treatment options include voice therapy, intralesional steroid injections, and surgical. Although vocal function improves and lesion regresses by vocal hygiene advice and voice therapy, each patient receives two therapy sessions per week for about 3 months of voice treatment in the form of a holi

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
Inclusion Criteria: * Patients who are diagnosed with minimal associated pathological lesions and complaining of dysphonia and not fit for surgery. * Patient not compliant to voice therapy (e.g. those from far residence). * Patients who refuse voice therapy. * Patient not responding to voice therapy. Exclusion Criteria: * Patients' refusal to be included in the study. * Patients having any other laryngeal voice disorders. * Patients not tolerating the naso-endoscopic examination. * Patients having allergy to the injected material after doing intradermal allergy test.
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What it tests

  • Intralesional injection of steroids (betamethasone), (Betafos®) and hyaluronidase (enzyme), (Hynidase®) into benign vocal fold lesions by a naso-fiberscope with a side working channel(Storz 11001UD1)
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Where

1 site
Mansoura University - Faculty of Medicine
Al Mansurah, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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