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Prospective Cohort of Patients With Fibrosing Interstitial Lung Disease Admitted for Acute Respiratory Failure

Recruitingn/aAges 18 Years - anyAllAssistance Publique - Hôpitaux de Paris
NCT06855004 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This prospective, multicenter study focuses on patients with fibrosing interstitial lung diseases (ILD) admitted to intensive care units (ICUs) for acute respiratory failure (ARF). ILD encompasses a group of heterogeneous disorders characterized by progressive fibrotic and inflammatory damage to the lung interstitium, often resulting in chronic respiratory failure. Acute respiratory failure in these patients is a severe and frequent complication caused by various factors, including infections, pulmonary embolism, cardiac decompensation, or acute exacerbation of fibrosis. Despite advances in treatment, ICU management of these patients remains a clinical and ethical challenge due to high mortality rates and limited evidence-based guidance. The study's primary objective is to assess 6-month survival following ICU admission for ARF in ILD patients. Secondary objectives include identifying p

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Hospitalization in intensive care for acute respiratory failure 2. Requirement for standard oxygen therapy with an O2 flow rate \> 6 l/min, high-flow oxygen therapy, or mechanical ventilation (non-invasive or invasive) 3. Age ≥ 18 years 4. Patient (male or female) with chronic interstitial lung disease (ILD) 1. Diagnosis of chronic ILD confirmed by a multidisciplinary discussion (MDD) prior to admission to intensive care, or 2. Diagnosis of chronic ILD made during the intensive care stay due to the acute episode and confirmed by an expert opinion. Exclusion Criteria: 1. Patient under legal guardianship or with restricted freedom 2. Patient hospitalized for psychiatric reasons or with a severe psychiatric illness causing a disability, subject to legal protection measures 3. Pregnant woman 4. Patient already enrolled in the study
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What it tests

  • Not listed
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Where

1 site
Hôpital Avicenne APHP Réanimation médico-chirurgicale
Bobigny, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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