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Menopausal HT for Women Living With HIV (HoT)

RecruitingPhase 4Ages 40 Years - 60 YearsFemaleAdvancing Clinical Therapeutics Globally for HIV/…
NCT06856174 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Women living with HIV have been shown to experience more frequent and severe hot flashes and night sweats (collectively known as vasomotor symptoms) as compared to women living without HIV. This correlates with disturbed sleep, increased depressive symptoms, increased anxiety, worse mental function, interference with activities of daily living including work, and worse overall quality of life. Hormone therapy is considered to be the most effective therapy for hot flashes and night sweats and the most appropriate choice to prevent bone loss at the time of menopause for women without HIV. However, the usefulness of hormone therapy has not been specifically studied in women living with HIV. This trial is being done to see if: * There is evidence to support the use of hormone therapy (estradiol with or without progesterone) for the treatment of hot flashes and night sweats in women living

Sign in to get the eligibility rules as simple questions to take to your doctor.

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📋 Eligibility rules (as published)
* Living with HIV * Assigned female sex at birth * Between the ages of 40 and 60 years * In the late menopausal transition (perimenopause) or early postmenopause * Experiencing hot flashes and/or night sweats * Willing and able to complete a daily diary * Does not have medical condition that would contraindicate hormone therapy * Not taking medications to treat hot flashes * Not taking medications that cannot be combined with hormone therapy * Receiving antiretrovirals (HIV medication) for more than 1 year * Not pregnant and willing and able to use at least non-hormonal birth control to prevent pregnancy * Willing and able to provide informed consent after discussion with the research staff
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What it tests

  • Transdermal estradiol gel
  • Micronized Progesterone
  • Placebo for estradiol gel
  • Placebo for micronized progesterone
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Where

23 sites
31788 Alabama CRS
Birmingham, United States
University of California, Los Angeles CARE Center CRS (601)
Los Angeles, United States
UCSD Antiviral Research Center CRS (701)
San Diego, United States
801 University of California, San Francisco HIV/AIDS CRS
San Francisco, United States
Harbor - UCLA Med. Ctr. CRS
Torrance, United States
University of Colorado Hospital CRS (6101)
Aurora, United States
The Ponce de Leon Center CRS (5802)
Atlanta, United States
Northwestern University CRS (2701)
Chicago, United States

…and 15 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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