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PPIs and In-Hospital Morbidity in Acute Variceal Bleeding With Chronic Liver Disease

RecruitingPhase 2Ages 18 Years - anyAllUniversidad Autonoma de Nuevo Leon
NCT06861478 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

With this study, the investigators pretend to describe intrahospital morbidity in patients living with cirrhosis (PLC) who present to the emergency department with variceal bleeding (VB). This study is a longitudinal, prospective, experimental, analytical single-center clinical trial. The study will be performed in the Hospital Universitario "Jose E. González" de la Factultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México. The studied population consists of adult-age patients with previous, recent, or new diagnoses of cirrhosis who present to the ED with VH without shock, infection, or acute or chronic disease with a \<30% probability of death (CLIF-C \<50). The exclusion criteria involve minor age, Acute Liver Failure (ALF), ICU patients, Hepatorenal Syndrome, sepsis or infection, and shock on admission except for hypovolemic and CLIF-C \>50 points. Eli

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📋 Eligibility rules (as published)
Inclusion Criteria * Adult * Cirrhosis * Variceal Bleeding with only endoscopic findings consistent with portal hypertension complications * Hypovolemic shock and Variceal bleeding Exclusion Criteria: * Shock of any type other than hypovolemic. * No cirrhotic patients * Patients that have severe Hepatic Encephalopathy at admission (West Haven 3 and 4) * Hepatorenal syndrome * Acute on chronic with CLIF-C \>50 points * Septic patients * Spontaneous Bacterial Peritonitis Elimination Criteria * Voluntary removal of the study * Violation of the study protocol * Patients in the no PBI group that need prolonged mecánica ventilación.
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What it tests

  • Omeprazole 40 mg IV
  • pantoprazole 40 mg iv
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Where

1 site
Hospital Universitario "Jose E. González" de la Facultad de Medicina, Universidad Autónoma de Nuevo León
Monterrey, Mexico
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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