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โ† Trials
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Impact of Individual Radiosensitivity on Late Toxicities of Radiosurgery in Essential Trigeminal Neuralgia

RecruitingNAAges 18 Years - anyAllCentre Hospitalier Universitaire de Nice
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In plain words

What the trial is, and whether it could suit you

Trigeminal neuralgia is intense, electric-shock-like facial pain, most often triggered by touch, chewing or speech. It results from dysfunction of the trigeminal nerve, the 5th cranial nerve. In most cases, no cause is found, and trigeminal neuralgia is termed "essential". In the first instance, treatment is based on medication. In cases of drug resistance, radiosurgery is a possible treatment option. This involves performing neurolysis, delivering a very high dose of ionizing radiation to the trigeminal nerve. The immediate success rate of radiosurgery is 80-90%. However, in the long term, around 30% of patients experience complications (mainly hypoesthesia of the face on the treated side, paresthesias, masticatory disorders, neuropathic pain) and 30% of patients experience a recurrence of neuralgic pain. Most of these complications are permanent, and there are very few effective treat

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Patients โ‰ฅ 18 years of age * Patients treated for trigeminal neuralgia by radiosurgery at CHPG more than 12 months ago * Treatment of the nerve with a 4 or 5 mm cone * Patient affiliated to social security * Patient agreement: obtaining the patient's non-opposition (France) or consent (Monaco) Exclusion Criteria: * Patients pre-treated for neuralgia by another invasive method: thermo coagulation, decompression surgery, radiosurgery... * Patients with multiple sclerosis (MS) * Secondary neuralgia * Hypoesthesia pre-existing treatment * Protected persons: persons deprived of their liberty, patients under guardianship or trusteeship
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What it tests

  • Radiation induced Lymphocyte Apoptosis diagnostic test
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Where

2 sites
Chu de Nice
Nice, France
Centre Hospitalier Princesse Grace
Monaco, Monaco
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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