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A Clinical Study on the Effect of Discontinuing Alendronate in Postmenopausal Women With Osteoporosis After a Treatment Period Without Fractures

RecruitingPhase 4Ages any - anyFemaleOdense University Hospital
NCT06864130 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to study the effects of discontinuation of Alendronate treatment for three years. The participants are postmenopausal women with osteoporosis, who have had a treatment period without fractures. The study will answer: * What is the rate of fragility fractures during the study? The hypothesis is that discontinuation of Alendronate after a fracture-free period does not raise the 3-year fracture risk. * Are there predictors of significant bone loss after discontinuation of Alendronate? The hypothesis is that clinical, biochemical, cellular, or molecular characteristics can predict bone loss. Researchers will compare the outcomes of discontinuation of Alendronate with continuing treatment. Participants will be randomly assigned to a group. Participants will: * Either take alendronate once weekly for three years OR discontinue their treatment * Visit the

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📋 Eligibility rules (as published)
Inclusion Criteria: * Female * Postmenopausal * Current treatment with Alendronate * Alendronate treatment \>3 år AND no fracture OR * Alendronate treatment \>5 år AND latest low energy fracture \> 3 years ago Exclusion Criteria: * T-score \< - 3,5 in hip (total hip or femoral neck) or lumbar spine * Treatment with systemic glucocorticoids, ongoing or within 12 months * Uncontrolled inflammatory disease * Active malignancy * eGFR \< 40 mL/min * Atypical femur fracture (ever) * OsteoNecrosis of the Jaw (active) * Unable to give inform consent
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What it tests

  • Alendronate 70mg weekly
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Where

7 sites
Aalborg University Hospital
Aalborg, Denmark
Bispebjerg Hospital
Copenhagen, Denmark
Esbjerg Og Grindsted Sygehus
Esbjerg, Denmark
Copenhagen University Hospital (Herlev)
Herlev, Denmark
Nordsjaellands Hospital (Hillerød)
Hillerød, Denmark
Hvidovre Hospital
Hvidovre, Denmark
Odense University Hospital
Odense, Denmark
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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