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Effect of Beta-blockers on Coronary Flow and Resistance in Patients With ANOCA

RecruitingPhase 4Ages 18 Years - anyAllVZW Cardiovascular Research Center Aalst
NCT06864234 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to learn whether beta-blockers can improve coronary blood flow and reduce resistance in patients with angina and no obstructive coronary arteries (ANOCA). The main questions it aims to answer are: * Do beta-blockers improve coronary blood flow in patients with ANOCA? * Do beta-blockers reduce coronary microvascular resistance in these patients? Researchers will compare a beta-blocker to a placebo to see if the medication has measurable effects on coronary circulation. Participants will: * Receive a beta-blocker or a placebo * Undergo specialized heart tests (such as coronary flow and resistance measurements) before and after treatment.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients undergoing diagnostic coronary angiography for suspected angina pectoris who are found to have ANOCA i.e. an FFR \>0.80 and no diameter stenosis \>50% * Normal, TIMI 3 flow at angiography * Stable haemodynamics Exclusion Criteria: * Clinical signs or symptoms of congestive heart failure * Severe valvular heart disease requiring either surgical or percutaneous intervention * History of coronary artery bypass grafting * Tortuous coronary anatomy in which wire manipulation could be complex * Heart rate \<60 beats per minute * Systolic blood pressure \<100 mmHg * Unable to give consent * LVEF\<40%
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What it tests

  • Saline (NaCl)
  • Metoprolol Tartrate
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Where

1 site
OLV Cardiovascular Center Aalst
Aalst, Belgium
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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