Exploration of Novel Imaging Biomarkers on OCT for Ublituximab Treatment Response in Multiple Sclerosis

Inclusion Criteria: For Ublituximab Group: 1. Ages 18-65 2. A diagnosis of relapsing MS (to include relapsing-remitting MS and active secondary progressive MS) according to 2017 Revised McDonald Criteria. 3. A recent referral for initiation of ublituximab for treatment of MS by the patient's treating physician. For Comparison Group: 1. Ages 18 - 65 2. A diagnosis of relapsing-remitting MS according to 2017 Revised McDonald Criteria. 3. Currently on a stable dose of disease modifying treatment for MS with no plans for alternative therapy for the following year. Exclusion Criteria: For Ublituximab Group: 1. Known eye disease that may, in the opinion of the screening ophthalmologist, preclude proper analysis of data in this study. This includes, but is not limited to diabetic retinopathy, macular degeneration, and glaucoma. 2. Treatment with any B-cell depleting disease modifying therapy for MS (i.e. rituximab, ocrelizumab, ofatumumab, ublituximab, etc.) within the past 12 months. 3. History of life-threatening infusion reaction on ublituximab or prior anti-CD20 therapy 4. Any chronic or active infection that would preclude anti-CD20 therapy. This may include but is not limited to active hepatitis B virus (HBV) confirmed by positive results for Hepatitis B surface antigen (HBsAg) and anti-HBV tests, tuberculosis, and human immunodeficiency virus (HIV). 5. Receipt of any live of live-attenuated vaccines within 4 weeks prior to first ublituximab administration For Comparison Group: 1. Known eye disease that may, in the opinion of the screening ophthalmologist, preclude proper analysis of data in this study. This includes, but is not limited to diabetic retinopathy, macular degeneration, and glaucoma. 2. Treatment with any B-cell depleting disease modifying therapy (i.e. rituximab, ocrelizumab, ofatumumab, ublituximab, etc.) within the past 12 months, or plans to initiate such a therapy in the following year.