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Dietary Strategy to Tackle Cognitive and Locomotor Abilities in Early Elderly Subjects

RecruitingNAAges 60 Years - 74 YearsAllUniversity Rovira i Virgili
NCT06871384 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Polyphenols, precisely resveratrol, with red wine as the most substantial source, was associated with improvements in cognitive function. Also, the loss of muscle mass and strength in elderly, that significantly increases dependency of these people, it could be attributed to alterations in gut microbiota through the "gut-muscle axis" and this underline the urgent need to efficiently find out any intervention or preventive approach via modulation of gut microbiota to improve muscle function in elderly. In this context, red wine polyphenols exert their effects through interaction with gut microbiota following the well-known two-way interaction between polyphenols and gut microbiota by promoting the proliferation of beneficial bacteria and increasing their abundance. Similarly, aging cognitive decline can be modulate by microbiota, notably through "gut-brain axis". Additionally, dietary pol

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📋 Eligibility rules (as published)
Inclusion Criteria: 1\. Men or women between 60-74 years old; Sensory tolerance to red wine; Written informed consent provided before the initial screening visit. Exclusion Criteria: 1. Men or women \>75 years old, 2. Hypoglucaemiant treatment or type 1 and type 2 diabetes mellitus diagnosed 3. Anaemia (hemoglobin ≤13 g/dL in men and ≤12 g/dL in women) 4. Subjects diagnosed of intestinal disorders such as chron disease, colitis ulcerous, and irritable bowel syndrome 5. To present a clinical active chronic disease 6. To present severe sarcopenia 7. To present cognitive impairment (MMSE ≤ 24 or clinical diagnosis of mild cognitive impairment or dementia) 8. Dietary allergies to: Mediterranean foods (eg, nuts), sulphytes or nitrates 9. Use of antioxidants supplements 10. Regular consumers of red wine who do not agree to change the consumption of red wine with alcohol to nonalcholized wine during the intervention 11. Chronic alcoholism 12. Current or past participation in a clinical trial or consumption of a research product in the 30 days prior to inclusion in the study 13. Failure to follow the study guidelines. For participation in the muscle biopsy, additional exclusion criteria included: Use of prescription anti-platelet medication; Prescription anticoagulant use (or antiaggregant, or acenocoumarol; Conditions which would reduce healing; or known allergy to lidocaine.
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What it tests

  • Nonalcoholic red wine group (Intervention group)
  • Drinking water group (Control group)
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Where

3 sites
Instituto de Ciencias de la Vid y del Vino-ICVV (Consejo Superior de Investigaciones Científicas-CSIC, Universidad de La Rioja, Gobierno de La Rioja)
Logroño, Spain
Lyfestyle, Microbiota and Health Unit, Health Sciences Faculty, University of La Rioja
Logroño, Spain
Universitat Rovira i Virgili, Facultat de Medicina i Ciències de la Salut, Functional Nutrition, Oxidation, and Cardiovascular Diseases Group (NFOC-Salut)
Reus, Spain
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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