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Blood Extracellular Vesicles as Predictive Recovery Biomarker After Stroke and Brain Injury

Recruitingn/aAges 18 Years - anyAllFondazione Don Carlo Gnocchi ETS
NCT06871800 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The rehabilitation outcome and recovery, in people after stroke or with vascular severe brain injury(vSBI), are difficult to predict. Moreover, the clinical management of patients during hospitalization is problematic due to complex clinical conditions and complications, e.g. healthcare-associated infections(HAIs). Today we still lack early objective biomarkers that could predict the patient's trajectory at admission. Extracellular vesicles are nanoparticles naturally released by cells in physiological and pathological conditions. As important actors of cellular communication between different organs and body districts, EVs are currently under investigation as an informative tool able to reflect the clinical conditions of patients. Using an optimized Surface Plasmon Resonance imaging (SPRi) based biosensor, our main objective is to assess the predictive capacity of biomarkers associated

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📋 Eligibility rules (as published)
Inclusion Criteria: * Disability deriving from first ischemic or haemorrhagic stroke detected by MRI or CT scan * Time from stroke onset or rehabilitation admission less than 1 month (for stroke) 3 months (for vSBI) * Need of inward rehabilitation * Signed informed consent by patient or legal representative Exclusion Criteria: * Subarachnoid haemorrhage * Cerebral venous thrombosis * Other previous neurological or psychiatric conditions * Autoimmune diseases * Previous severe and chronic infections conditions (e.g. tuberculosis, HIV/AIDS) * Neoplasms or other malignant conditions * Immunomodulatory medications (immunosuppressants).
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What it tests

  • blood withdrawal
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Where

3 sites
IRCCS "Don Gnocchi", Fondazione Don Gnocchi Onlus
Florence, Italy
IRCCS "S. Maria Nascente", Fondazione Don Gnocchi Onlus
Milan, Italy
"S. Maria ai Colli - Presidio Ausiliatrice", Fondazione Don Gnocchi Onlus
Torino, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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