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Trophallergen Prick Tests (PT) : Influence of Food Sample Shelf Life on the Reproducibility of PT Results

RecruitingNAAges 18 Years - anyAllCentre Hospitalier Régional d'Orléans
NCT06872996 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Prick tests (PT) are the standard skin tests used in the investigation of immediate IgE-mediated food allergies. Their use as a first-line tool in allergological investigations is strongly recommended by the European Academy of Allergy and Clinical Immunology (EAACI). These tests involve locally reproducing histamine release manifestations in the epidermis by superficially introducing an allergen to confirm or rule out its role in the onset of clinical symptoms compatible with an allergy. During the diagnostic management and follow-up of patients with food allergies, the technique used is the "prick to prick" method, due to the lack of reliable access to many standardized commercial food extracts. This method involves piercing the food with a sterile lancet (to deposit food content on its surface) and then making a superficial skin puncture with the same device on the anterior surface of

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Aged 18 and over. 2. Having a diagnosis of food allergy(ies) due to one or more of the food allergen studied, previously made by an allergologist, of grade 2 to 3 according to the Ring and Messmer classification. 3. Having given consent to participate in the study. The diagnosis is made by the allergologist of the department due to the presence of a compatible clinical history implicating the tested allergen, the presence of evidence of sensitization to the allergen (positive prick-test and/or positive specific IgE assays), or even a positive oral allergen reintroduction test. Exclusion Criteria: 1. Anaphylactic reaction dating less than 6 weeks 2. Hospitalization for asthma in the past 3 months 3. History of grade 4 anaphylactic reaction according to the Ring and Messmer classification. 4. Systemic antihistamine treatment in the 7 days preceding the test 5. Systemic beta-blocker treatment on the day of the test. 6. Protected person (under guardianship or curatorship) 7. Person under judicial supervision 8. Persons deprived of liberty 9. Person not affiliated with a social security insurance 10. Pregnant or breastfeeding women
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What it tests

  • Prick-test
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Where

1 site
Centre Hospitalier Universitaire d'Orléans
Orléans, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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