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Is There a Need for Luteal Support in Modified Natural Cycle Frozen Embryo Transfer Cycles

RecruitingPhase 4Ages 18 Years - 40 YearsFemaleDunamenti REK Istenhegyi IVF Center
NCT06875752 on ClinicalTrials.gov โ†—
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In plain words

What the trial is, and whether it could suit you

Without progesterone there is no pregnancy. Following ovulation, the endocrine function of the follicle changes and progesterone replacing estradiol becomes its main secretory product. In the follicular phase the increasing amount of estradiol secreted by the growing follicle builds up the endometrium, while in the luteal phase progesterone, the main product of the corpus luteum, prepares the endometrium for implantation. This process is called decidualization. If implantation occurs, human chorionic gonadotropin (hCG) secreted by the trophopblasts maintains the function of the corpus luteum. This continued activity is required to be maintained up to week 7-9 of gestation when the hormone secreting activity is taken over by the placenta (luteo-placental shift) and the corpus luteum regresses. During in vitro fertilization (IVF) gonadotropins are used to induce multifollicular developmen

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Age 18-40 years at the time of vitrification * At least one good quality blastocyst frozen * Planned 1 blastocyst transfer * \<3 failed previous ETs * Cycle length between 21-35 days * Body mass index (BMI): 18-35 kg/m2 * Intact uterine cavity based on hysteroscopy, hysteron-salpingogram, salina sonohysterogram * Consent to participate Exclusion Criteria: * Age \<18 of over 40 at the time of vitrification * BMI: \<18 kg/m2 or \>35 kg/m2 * Planned transfer of more than 1 embryo * Irregular cycles (\<21 or \>35 days) * Use of a protocol other than the modified natural cycle frozen embryo transfer * Lack of good morphology blastocysts * No evidence for spontaneous follicle development (no dominant (\>17 mm) follicle by day 20 of cycle) * Patient with a history of recurrent miscarriages * Presence of a hydrosalpinx * Irregular uterine cavity * Positive test for HIV, hepatitis B or C * Lack of consent
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What it tests

  • no luteal support
  • Vaginal Progesterone
  • Progesterone plus HCG
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Where

5 sites
Dunamenti REK Istenhegyi IVF Center
Budapest, Hungary
Dunamenti REK Gyor IVF Center
Gyล‘r, Hungary
University of Pecs, Dept. OBGYN, Reproductive Center
Pรฉcs, Hungary
University of Szeged, Reproductive Medicine Institute
Szeged, Hungary
Dunamenti REK Tapolca IVF Center
Tapolca, Hungary
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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