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Postprandial Metabolome and Metabolic Flexibility

RecruitingNAAges 18 Years - 30 YearsAllInstituto Nacional de Medicina Genomica
NCT06878781 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Metabolic flexibility is a process in which the body can switch energy substrates in different physiological states. This flexibility plays an important role in an individual's health because losing it increases the risk of obesity, metabolic syndrome, insulin resistance, and type 2 diabetes. Considering that humans spend most of their awakening hours in a postprandial (PP) state, an organism's metabolic flexibility (MF) to respond to a standardized meal's consumption would provide information on the individual's metabolic health. The PP response to glucose following an oral glucose tolerance test or consumption of a high-carbohydrate meal is well described; however, few studies assess the FM and PP metabolome using mixed meals with different macronutrients. The investigators address how metabolic flexibility and metabolome change after consuming standardized meals with different macronu

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📋 Eligibility rules (as published)
Inclusion Criteria: * be over 18 years of age and under 30 years of age; * without active drug addictions: smoking, alcoholism, and/or drug addiction; * in female subjects: regular menstrual cycles; * give written consent for their inclusion in the study. Exclusion Criteria: * subjects with any pathology that requires medication or special treatment, such as type 2 diabetes mellitus, high blood pressure, dyslipidemia, polycystic ovary syn-drome, autoimmune, thyroid, kidney, neurological diseases, and cancer; * pregnant or lactating women; * subjects with problems with chewing, salivation, and swallowing. Elimination criteria: * subjects who only have samples (blood and calorimetry) from one study period (fasting or postprandial); * subjects who only have samples (blood and calorimetry) of a metabolic challenge; * subjects who have an infection at the scheduled appointment; * subjects who withdraw their informed consent
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What it tests

  • High carbohydrate challenge
  • High lipid challenge
  • High proteinchallenge
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Where

1 site
Berenice Palacios-Gonzalez
Mexico City, Mexico
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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