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Radiological Prediction of Response to Neoadjuvant Chemoimmunotherapy for Triple-negative Breast Cancer

RecruitingNAAges 18 Years - 75 YearsFemaleCentre Henri Becquerel
NCT06879704 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The aim of our study is to find the best imaging technique, alone or in combination, that can best predict a complete response (absence of tumour cells). It also seems important to identify blood markers able to predict which patients will benefit most from treatment, with a view to personalising them, or which patients will be most at risk of toxicities, particularly related to immunotherapy, with a view to personalising monitoring.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Signed informed consent * Patient with histologically proven TNBC * Indication for neo-adjuvant chemo-immunotherapy treatment * Age between 18 and 75 * Affiliated or beneficiary of a social protection scheme Exclusion Criteria: * Pregnant or breast-feeding women * Contraindication to immunotherapy * Inflammatory breast cancer (T4d) * Metastatic patients * Allergies to iodine or gadolinium * Patient with an augmentation prosthesis (for angiography/mammography) * Claustrophobic patients * Renal contraindication to contrast products according to SFR-CIRTACI * Ferromagnetic material * Uncontrolled diabetes (blood glucose \>10 mmol/L) * Patient unable to understand the study for any reason or to comply with the constraints of the trial (language, psychological, geographical problems, etc.). * Patient under guardianship, curatorship or safeguard of justice
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What it tests

  • Imaging assessment
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Where

1 site
Centre Henri Becquerel
Rouen, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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