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Anti-CD25 rhMAb for aGVHD Prevention in High-Risk Adults Using the daGOAT Model

RecruitingPhase 2Ages 16 Years - anyAllInstitute of Hematology & Blood Diseases Hospital…
NCT06880419 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

To assess the efficacy and safety of using recombinant humanized anti-CD25 monoclonal antibody injection as a prophylactic strategy for reducing the incidence of severe acute graft-versus-host disease (aGVHD) in adult patients at intermediate to high risk, as predicted by the dynamic aGVHD Onset Anticipation Tianjin (daGOAT) model, following allogeneic hematopoietic stem cell transplantation (allo-HSCT).

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Age ≥ 16 years, regardless of gender. 2. Patients with hematologic disorders who are scheduled to receive allo-HSCT. 3. Voluntarily join this study, sign the informed consent form, have good compliance, and be willing to cooperate with follow-up. Exclusion Criteria: 1. Patients who have received a second or multiple transplants. 2. Patients who are allergic to, or intolerant of, a recombinant humanized anti-CD25 monoclonal antibody injection. 3. Pregnant or lactating female patients or female patients who are unable to take effective contraceptive measures during the entire trial period.
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What it tests

  • Recombinant Humanized Anti-CD25 Monoclonal Antibody Injection
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Where

1 site
Institute of Hematology & Blood Diseases Hospital
Tianjin, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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