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Human Umbilical Cord Mesenchymal Stem Cells Treatment in Sepsis

RecruitingEARLY Phase 1Ages 0 Years - 65 YearsAllDaping Hospital and the Research Institute of Sur…
NCT06882811 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The primary objective: To evaluate the efficacy of intravenous infusion of universal UC-MSCs and CD83+MSCs subpopulation injection in the treatment of sepsis by using the 28-day survival rate of the subjects as the primary efficacy criterion.The secondary objectives: 1. To systematically evaluate the safety of universal UC-MSCs and CD83+MSCs subpopulation in the treatment of sepsis; 2. To provide theoretical basis and clinical research data for establishing a safe, effective and feasible clinical treatment plan for sepsis using stem cells.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age: 0-65 years old, diagnosed with sepsis * Clinical diagnosis of sepsis (based on Sepsis 3.0 International Guidelines) * Confirmed or suspected infection Exclusion Criteria: * Violation of medical ethics * Significant confounding factors likely to bias study outcomes * Poor adherence to the study protocol * Concurrent participation in other clinical trials * Specific medical conditions: 1. History of chronic enteritis, neuropsychiatric disorders, or transplantation (bone marrow, lung, liver, pancreas, or small intestine) 2. Severe primary diseases affecting survival (e.g., life-limiting hepatic, renal, or endocrine disorders) or psychiatric disorders 3. History of hypersensitivity or severe adverse reactions to biological products 4. Imminent terminal status (e.g., septic shock, life expectancy \<7 days) 5. Foreseeable risk of medical errors or disputes during hospitalization 6. Active drug-resistant infections 7. History of malignancy at screening 8. Pregnancy, lactation, or plans for pregnancy within the next year
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What it tests

  • CD83-positive MSC
  • regulatory MSC
  • control solution
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Where

1 site
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Chongqing, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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