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Dietary Intervention to Improve Fertility in Women With Endometriosis Undergoing IVF

RecruitingNAAges 18 Years - 39 YearsFemaleFondazione IRCCS Ca' Granda, Ospedale Maggiore Po…
NCT06885125 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this randomized controlled trial is to assess whether a 12-week anti-inflammatory diet can improve fertility outcomes in women with endometriosis undergoing In Vitro Fertilization (IVF). The main questions are: * Does the anti-inflammatory diet reduce the rate of inadequate ovarian response to hormonal stimulation (retrieval of ≤3 oocytes)? * Does it improve secondary outcomes such as embryo quality, pregnancy rates, inflammation markers, and quality of life? Researchers will compare two groups: * Women receiving standard IVF protocols. * Women undergoing the same IVF protocol plus the anti-inflammatory diet. Participants will: * Be randomized into one of the two groups. * Follow dietary counseling sessions and complete dietary assessments (diet group). * Provide biological samples (e.g., plasma, vaginal and fecal swabs, and follicular fluid) before and after the dietar

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age \< 40 years * Pregnancy seeking for more than 12 months * Regular menstrual cycle, i.e. mean cycle interval between 21 and 35 days * Ultrasonographic diagnosis of ovarian endometriomas or deep peritoneal endometriosis. * Antral Follicle Counts (AFC) ≥ 5 (no other cause of reduced ovarian reserve). * Absence of ureteral stenosis or intestinal subocclusive symptoms Exclusion Criteria: * Contraindication to pregnancy * Hydrosalpinx * Endometriomas with a mean diameter \> 4 cm * Submucosal fibroids or large intramural or subserosal fibroids (≥ 5 cm). * Doubtful sonographic findings that do not allow to reliably rule out malignancy. * severe male factor (\<1 million sperm/ml)
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What it tests

  • anti-inflammatory diet
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Where

1 site
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Milan, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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