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Pharmacist-Led Treat-to-Target Urate Lowering Therapy in Patients With Gout

RecruitingNAAges 18 Years - anyAllVA Office of Research and Development
NCT06887452 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study will compare two different approaches to manage medications that lower uric acid levels. This study will be conducted at five VA medical centers across the United States and will take 4-5 years to complete. Individual participation will last up to two years.

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📋 Eligibility rules (as published)
Inclusion Criteria: * US Veterans with physician-diagnosed * Documented hyperuricemia (SU \> 6.8 milligrams per deciliter) * Satisfy American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) gout classification criteria * Report 1 or more flares in the prior 6 months * Receipt of a new urate-lowering therapy (ULT) prescription (allopurinol or febuxostat) initiated by a primary care provider or longer term ULT but otherwise satisfy the flare/SU criteria Exclusion Criteria: * Any patient intolerant or unable to take urate-lowering therapies (allopurinol or febuxostat) * Patients with a rheumatology encounter within the prior 3 months * Patients on an allopurinol dose \> 300 or a Febuxostat dose \> 40 * Patients with stage IV/V Chronic Kidney Disease (CKD) * Patients with a life expectancy \< 12 months * Patients with a concomitant medication of azathioprine or 6-MPC (urate-lowering therapy contraindicated)
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What it tests

  • Pharmacist-Led
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Where

5 sites
Omaha VA Nebraska-Western Iowa Health Care System, Omaha, NE
Omaha, United States
VA Portland Health Care System, Portland, OR
Portland, United States
Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA
Philadelphia, United States
VA Salt Lake City Health Care System, Salt Lake City, UT
Salt Lake City, United States
VA Puget Sound Health Care System Seattle Division, Seattle, WA
Seattle, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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