Mpox Comprehensive Assessment for Responsive Immunisation in Emergency Outbreaks

Inclusion Criteria: * Healthy males and females aged between ages 5-80 years, who are able and willing to provide informed consent and will comply with the study requirements. * Group 1 (suspected exposure cohort) only * Live within or adjacent to an epidemiologically identified region of Mpox transmission * Close contacts of those with microbiologically confirmed Mpox * Group 2 (post-exposure/vaccinated cohort) only * Previous clinically or microbiologically confirmed Mpox or confirmed previous vaccination with a smallpox/MVA vaccine * Fully recovered from Mpox infection * Group 3 (control cohort) only: * Asymptomatic with no known exposure to Mpox Exclusion Criteria: * Unwilling or unable to provide informed consent to take part * Unwilling or unable to comply with study procedures * History of any suspected or confirmed disorder of the immune system that, in the opinion of the investigators, might impair the results of the study * Have a bleeding disorder deemed significant by a member of the study team * Pregnant or breast-feeding females * Group 1 (suspected exposure cohort) only * Known history of Mpox infection * Current symptoms consistent with Mpox * Known exposure to Mpox in the last month * Group 2 (post-exposure/vaccinated cohort) only * Participants with any ongoing symptoms of Mpox, indicating incomplete recovery. * Group 3 (control cohort only) * Symptoms of Mpox * Known exposure to Mpox in the last month