A Platform Study of Epigenetic Therapy Before Prostatectomy in Men With Prostate Cancer

Inclusion Criteria * Men electing to undergo radical prostatectomy with preoperative tissue available. * Age ≥18 years * Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0 or 1 * Adequate organ function defined by: * AST and ALT \< 2.5 x ULN * Total bilirubin \< 1.5 x ULN * Platelets \> 90 x 1000/μL * Hemoglobin (Hgb) \> 8.5 g/dL * Serum Creatinine (Cr) \<1.5 x ULN or eGFR \> 30 mL/min * People with partners of childbearing potential in circumstances that may result in the pregnancy, must have had a successful vasectomy (with medically confirmed lack of sperm that are alive) OR must either practice complete abstinence or agree to use adequate contraception (latex or synthetic condom during sexual contact with a female of childbearing potential) from the start of study treatment until 3 months following last dose of study intervention. Subjects should not donate sperm on study, during interruptions in treatment and for 3 months following completion of study drug treatment. * Written informed consent obtained from subject and ability for subject to comply with the requirements of the study. Exclusion Criteria * Active intercurrent illness or malignancy requiring therapy outside of prostate cancer. * Other anti-cancer therapy (chemotherapy, hormonal therapy, radiation therapy, surgery, immunotherapy, biologic therapy, or tumor embolization) * Currently participating in a study using an investigational, medicinal anti-cancer agent within 4 weeks prior to first dose of epigenetic therapy.