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Cardiovascular and Endothelial Markers During OGTT Before and at Six and Twelve Months Post-treatment in Women With PCOS

Recruitingn/aAges 18 Years - 45 YearsFemaleAttikon Hospital
NCT06889454 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The aim of the present study is to investigate a) the presence of subclinical markers of vascular, myocardial and endothelial function in women with PCOS b) the acute alterations in these markers during the oral glucose tolerance test (OGTT) c) the impact of potential treatment interventions in these markers.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Age \> 16 years old 2. Diagonis of PCOS according to Rotterdam criteria: presence of two of the three of the following: * Clinical or biochemical hyperandrogenism * Anovulation or oligo-ovulation * Polycystic ovarian morphology (PCOM) 3. Absence of treatment for PCOS the last six months 4. Patients who have the ability to understand and sign the consent form. Exclusion Criteria: 1. Disorders with clinical presentation similar to PCOS: thyroid disease, hyperprolactinemia, and non-classic congenital adrenal hyperplasia (primarily 21-hydroxylase deficiency by serum 17-hydroxyprogesterone \[17-OHP\]), Cushing syndrome, acromegaly 2. Treatment with contraceptive or metformin 3. Type 2 diabetes mellitus 4. Treatment for diabetes 5. Pregnancy 6. Lactation 7. Malignancy
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What it tests

  • GLP-1 receptor agonist
  • Oral contraceptive
  • Metformin
  • Lifestyle modification
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Where

1 site
Attikon University General Hospital
Chaïdári, Greece
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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