AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

โ† Trials
๐Ÿงช

Effect of Daily Mixed Spice Consumption on Memory Function

RecruitingNAAges 50 Years - 80 YearsAllUniversity of California, Los Angeles
๐Ÿ’ฌ

In plain words

What the trial is, and whether it could suit you

The aging process entails a multitude of structural and functional alterations within the brain, culminating in a gradual and progressive decline in cognitive function. Recent research has indicated that various spices may hold the key to enhancing brain health and combating the effects of aging on cognitive abilities. The hypothesis is that a mixture of spices, acknowledged for their reported memory protection potential, may yield a more potent beneficial effect on memory function than a single spice. The spice mixture will be used at culinary dose, and therefore side effects are anticipated. In this study, the effects of spice mixture will be evaluated, as well as their anti-oxidant, and anti-inflammatory properties. The proposed pilot study will include 50 adults (ages 50-80), exhibiting typical age-related mild cognitive decline, excluding dementia or major neurocognitive disorders.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: 1. Participants are required to have clinical histories consistent with normal aging or mild cognitive impairment (MCI). 2. Age 50 to 80 years. 3. Adequate visual acuity and hearing to allow neuropsychological testing. 4. Screening laboratory tests without significant abnormalities that might interfere with the study. \- Exclusion Criteria: 1. Diagnosis of probable Alzheimer's disease or any other dementia (e.g. vascular, Lewy body, frontotemporal) 2. Evidence of other neurological or physical illness that can produce cognitive deterioration. Determination of dementia will be based on the clinical evaluation including assessment of functional abilities, and cognitive screening (using the Mini Mental State Examination 3. Evidence of Parkinson's disease as determined by the motor examination (items 18-31) of the Unified Parkinson's Disease Rating Scale \[38\]. 4. Uncontrolled hypertension (systolic blood pressure (BP) \> 170 or diastolic BP \> 100). 5. Consume spices regularly \> 5g day 6. Allergy or sensitivity to spices. Subjects will be excluded if there is a prior history of such sensitivity. Since these foods are commonly eaten and allergies are rare, subjects should be aware of this sensitivity prior to entering the study. To determine this, a positive history of spices ingestion without incident will be requested. In addition, any subject with a history of allergy or anaphylaxis of any kind will be excluded. 7. Current diagnosis of any major psychiatric disorder according to the DSM-IV TR criteria (APA, 2000). 8. Current diagnosis or alcoholism or substance addiction. 9. Eating a high fiber/polyphenol diet or taking any medication or dietary supplement which interfere with the absorption of polyphenols. 10. Frequently using prebiotics, probiotics, yogurt, and/or any fiber supplements
๐Ÿ’Š

What it tests

  • Mixed spices
  • Placebo
๐Ÿ“

Where

1 site
UCLA Center for Human Nutrition
Los Angeles, United States
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
๐Ÿ›ก๏ธ

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it โ€” not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use ยท Privacy