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Timing of Renal Replacement Therapy Initiation in Tumor Lysis Syndrome

Recruitingn/aAges 18 Years - anyAllUniversity Hospital, Bordeaux
NCT06889974 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The TENDERS study aims to evaluate the impact of the timing of renal replacement therapy (RRT) initiation on outcomes in patients with tumor lysis syndrome (TLS) and associated acute kidney injury (AKI). The study will compare early versus delayed RRT initiation, examining the effect on renal function at 30 days post-treatment.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults aged ≥18 years. * Hospitalized in the ICU between January 1, 2013, and December 31, 2023. * Diagnosed with a hematologic malignancy or solid tumor requiring chemotherapy. * Diagnosed with TLS based on the presence of two or more biochemical criteria (e.g., hyperkalemia, hyperphosphatemia, hyperuricemia, hypocalcemia) within 3 days before or 7 days after chemotherapy initiation. Exclusion Criteria: * Patient or family opposition to data collection for research purposes. * Incomplete medical records that preclude data extraction.
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What it tests

  • Not listed
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Where

10 sites
CHU d'Angers
Angers, France
Hôpital Pellegrin
Bordeaux, France
Hôpital la cavale blanche
Brest, France
CHU Dupuytren 1
Limoges, France
Hôtel-Dieu
Nantes, France
CHR d'Orléans
Orléans, France
CH de Pau
Pau, France
Centre Urgences-Réanimations
Rennes, France

…and 2 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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