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Comparing Hydrocortisone and Prednisolone for Community Acquired Pneumonia (CAP)

RecruitingPhase 4Ages 18 Years - anyAllCopenhagen Respiratory Research
NCT06892197 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this cluster randomized controlled trial is to determine the optimal treatment for community aquired pneumonia (CAP). The study compares the effects and side effects of hydrocortisone and prednisolone in patients above 18 years old diagnosed with severe CAP. The main question is whether there is a difference in all cause mortality within thirty days. Participants will be randomized to receive treatment with either hydrocortisone or prednisolone.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age \> 18 years * Diagnosis of severe CAP for who the physician in charge decides for corticosteroid therapy for severe CAP. Exclusion Criteria: * Admitted \>24 h * Pregnant or breastfeeding women * Active tuberculosis or fungal infection * Pneumonia caused by influenza * Intolerance to either study drug
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What it tests

  • Methylprednisolone (drug)
  • hydrocortisone
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Where

14 sites
Bornholm Hospital
Rønne, Denmark
Amager Hospital
Copenhagen, Denmark
Bispebjerg Hospital
Copenhagen, Denmark
Frederiksberg Hospital
Frederiksberg, Denmark
Gentofte Hospital
Hellerup, Denmark
Herlev Hospital
Herlev, Denmark
Hvidovre Hospital
Hvidovre, Denmark
Nordsjællands Hospital
Hillerød, Denmark

…and 6 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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