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Comparing Hydrocortisone and Prednisolone for Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD)

RecruitingPhase 4Ages 40 Years - anyAllCopenhagen Respiratory Research
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In plain words

What the trial is, and whether it could suit you

The goal of this cluster randomized controlled trial is to determine the optimal treatment for Acute Exacerbation of Chronic Obstructive Pulmonary Disease. The study compares the effects and side effects of hydrocortisone and prednisolone in patients above 40 years old diagnosed with chronic obstructive pulmonary disease with acute exacerbation. The main question is whether there is a difference in readmission for COPD excerbation or all cause mortality within thirty days. Participants will randomized to receive treatment with either hydrocortisone or prednisolone.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥40 years * Chronic obstructive pulmonary disease with acute exacerbation, unspecified: ICDJ44 Exclusion Criteria: * All diagnoses that would merit treatment with a specific corticosteroid * Pregnant or breastfeeding women * Active tuberculosis or invasive fungal infection
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What it tests

  • Methylprednisolone (drug)
  • Hydrocortisone
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Where

14 sites
Bornholm Hospital
Rønne, Denmark
Amager Hospital
Copenhagen, Denmark
Bispebjerg Hospital
Copenhagen, Denmark
Frederiksberg Hospital
Frederiksberg, Denmark
Gentofte Hospital
Hellerup, Denmark
Herlev Hospital
Herlev, Denmark
Hvidovre Hospital
Hvidovre, Denmark
Nordsjællands Hospital
Hillerød, Denmark

…and 6 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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