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A Real World Study About PMN

Recruitingn/aAges 18 Years - anyAllWei Chen
NCT06893328 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The investigators designed a randomized, controlled, multicenter clinical study to compare the efficacy and safety of rituximab combined with hormones versus rituximab monotherapy in the treatment of primary membranous nephropathy. At the same time, the investigators conducted a real-world study on patients who did not meet the inclusion and exclusion criteria or were unwilling to enter the RCT cohort, to further observe the trial results in a broader population.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1\. Diagnosed as primary membranous nephropathy (PMN) by renal biopsy; 2. Aged over 18 years; 3. An average 24-hour urine protein ≥ 3.5g twice a week after treatment with ACE inhibitors or ARBs for at least 3 months. \- Exclusion Criteria: 1. With secondary membranous nephropathy (such as hepatitis B and C, systemic lupus erythematosus, drug therapy, malignant tumors and other secondary causes); 2. Active infection, such as active hepatitis B or hepatitis C, tuberculosis (evidence of active tuberculosis infection within 1 year), or human immunodeficiency virus HIV infection (positive for anti-HIV antibodies), etc. 3. A history of immunodeficiency, including other acquired or congenital immunodeficiency diseases, or organ transplantation. \-
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What it tests

  • Not listed
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Where

1 site
Wei Chen
Guangzhou, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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