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The Effect of Griffonia Simplicifolia on Pain Intensity, Central and Peripheral Sensitization, Painmodulation in Healthy Volunteers

RecruitingNAAges 18 Years - 99 YearsAllMedical University of Graz
NCT06893822 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This planned study is based on a randomized, placebo-controlled cross-over design. Griffonia simplicifolia contains the serotonin-precursor 5-hydroxytryptophan (5-HTP), an endogenous amino acid. 5-HTP can cross the blood-brain barrier and is converted to serotonin. Low serotonin levels are associated with depression, anxiety disorders and sleep disorders, among others. Griffonia simplicifolia is marketed as a food supplement in accordance with EU Directive 2002/46/EC. Several clinical studies have examined the efficacy of 5-HTP in chronic pain conditions. The data suggest a clinical analgesic efficacy, without, however, allowing conclusions about the underlying mechanisms. These have not yet been investigated in a human experimental pain model. The aim of the study is to investigate the influence of 5-HTP in peripheral and central sensitization, as well as descending inhibitory pathway

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📋 Eligibility rules (as published)
Exclusion Criteria: * pregnancy or breastfeeding. * renal or hepatic insufficiency * neurological/dermatological/cardiovascular diseases * chronic pain and/or use of analgesics * intake of antidepressants * intake of MAO inhibitors * intake of sleep medication * intake of St. John's wort * allergy to Griffonia simplicifolia
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What it tests

  • Griffonia simplicifolia
  • Placebo
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Where

1 site
Medical University of Graz
Graz, Austria
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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