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Guiding Opioid Administration by Nociception Level Index (NOL) in Patients With Regional Anesthesia

RecruitingNAAges 18 Years - anyAllUniversitätsklinikum Hamburg-Eppendorf
NCT06905340 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

General anesthesia consists of a combination of hypnotic drugs to achieve unconsciousness and opioid analgesics to ensure antinociception. An alternative approach to the intraoperative administration of high-potency opioids to achieve antinociception during surgery is combining general anesthesia with regional anesthesia. Modern general anesthesia aims to avoid an overdose of opioid analgesics and reduce side effects of opioid administration. Quality and safety of general anesthesia are of major clinical importance and can be improved by adjusting the opioid analgesics to the optimal individual dose needed. In current clinical practice, opioid dosage is usually determined by clinical judgment. However, different monitoring devices estimating the effect of nociception during unconsciousness have become commercially available. One of the most recent commercially available nociception indi

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📋 Eligibility rules (as published)
Inclusion Criteria: \- Patients undergoing elective trauma or orthopedic surgery with a combination of general and regional anesthesia Exclusion Criteria: * Preexisting therapy with cardiac glycosides or pacemakers * Cardiac arrhythmia (atrial fibrillation, atrioventricular block \> I°) * Chronic opioid misuse * Intraoperative treatment with ketamine, beta-adrenergic agonists, or clonidine * Serious peripheral or cardiac autonomic neuropathy * Inability to specify the postoperative pain level * Postoperative treatment in an ICU
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What it tests

  • NOL (Nociception Level Index)
  • Control (Standard treatment)
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Where

1 site
Department of Anesthesiology; Center of Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg Eppendorf
Hamburg, Germany
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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