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Brain Activity During Complex Walking in People With Atypical Parkinsonian Syndromes

Recruitingn/aAges any - anyAllKarolinska Institutet
NCT06906276 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Every-day life means being part of a complex environment and performing complex tasks that usually involve a combination of motor and cognitive skills. However, the process of aging or the sequelae of neurological diseases such as atypical Parkinson's disease (APD) compromises motor-cognitive interaction necessary for an independent lifestyle. While motor-cognitive performance has been identified as an important goal for sustained health across different clinical populations, little is known about underlying brain function leading to these difficulties and how to best target these motor-cognitive difficulties in the context of rehabilitation and exercise interventions. The challenge of improving treatments of motor-cognitive difficulties (such as dual-tasking and navigation) is daunting, and an important step is arriving at a method that accurately portrays these impairments in an ecolo

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📋 Eligibility rules (as published)
Inclusion Criteria: * clinical diagnosis of PSP according to Movement Disorder Society (MDS) (2017) or * MSA according to MDS criteria (2022) * the ability to walk with or without a mobility device for ≤5 minutes continuously Exclusion Criteria: * cognitive difficulties affecting the ability to understand and/or follow verbal/written - instructions * severe freezing of gait * Severe hearing or visual impairments that affect participation in the assessments * Other neurological diseases * Other diseases that can affect gait or balance.
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What it tests

  • Assessment of brain activity with fNIRS and behavioural assessments (motor, motor-cognitive and cognitive) during three complex walking conditions.
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Where

1 site
Karolinska Institutet
Solna, Sweden
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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