Cohort Evaluation of Body Fluids Early Detection of Cancer in High-risk Individuals

Inclusion Criteria increased risk cohort: 1. Are aged 18 or more 2. Have a cumulative 3-year risk of developing any cancer ≥ 4% (including the situation specific cancers + other cancers) defined as follows: 1. Situations at increased risk of breast cancer * Women carrying germline pathogenic (P) or likely pathogenic (LP) variants of BRCA1, BRCA2, TP53, PALB2, PTEN, CDH1 genes without prophylactic mastectomy, aged ≥ 40 years, or * Men with germline (P) or (LP) variants in the BRCA2 gene, aged ≥ 40 years, or * Women with a personal history of an histological atypical breast lesion in the past 5 years and aged ≥ 50 years, or * Women with a personal history of unilateral breast cancer (including ductal carcinoma in situ) diagnosed more than 5 years before inclusion, and currently aged ≥ 60 years, or * Women who received chest radiotherapy before age 30 years and currently aged ≥ 25 years, or * Women with an invasive breast cancer risk \> 2.5% over the next 5 years, as defined by risk scores +/- genotyping, and aged ≥ 50 years, or * Individuals identified at increased risk in MyPeBS trial (\> 2.5% over the next five years) (www.mypebs.eu) can be eligible for the study, if aged ≥ 50 years, or 2. Situations at increased risk of gynaecological cancer * Women with a Lynch syndrome - germline (P) or (LP) variants in hMLH1, MSH2, hMLH6, PMS2, and aged ≥ 30 years, or * Women carrying germline (P) or (LP) variants of BRCA1, BRCA2, PALB2, RAD51C or RAD51D, PTEN genes without prophylactic oophorectomy, aged ≥ 40 years, or POLE and POLD1, and aged \> 30 years; or SMARCA4 or DICER1 and aged \> 18 years or 3. Situations at increased risk of colorectal cancer * Men or women with a Lynch syndrome - germline (P) or (LP) variants in hMLH1, MSH2, hMLH6, PMS2, APC, POLE, POLD1, BMPR1A, SMAD4 or biallelic MuTYH genes, and aged ≥ 40 years, or * Individuals with an increased risk of colorectal cancer defined by the following criteria and aged ≥ 50 years, or * First-degree relative diagnosed with colorectal cancer before the age of 60 years, or * Two or more 1st degree relatives diagnosed with colorectal cancers at any age, or * Personal history of any colorectal adenoma before the age of 50 years or adenomatous polyps \> 1 cm, villous adenomas, dysplastic adenomas, or ≥ 3 adenomatous polyps after the age of 50 years, or * Inflammatory Bowel Disease (Crohn's Disease; Ulcerative Colitis) after the age of 50 years, or 4. Situations at increased risk of upper gastrointestinal cancers * Carriers of an STK11 or CDH1 germline (P) or (LP) variants and aged \> 30, or * Individuals with an increased risk of esophageal adenocarcinoma: Barrett's esophagus with high-grade dysplasia, or 5. Situations at increased risk of hepatic cancers \- Individuals at increased risk of hepatocellular carcinoma because of documented liver fibrosis or cirrhosis (whether secondary to non-alcoholic steatohepatitis, alcohol-related, or virus-related), or 6. Situations at increased risk for pancreatic cancers * Patients with a family history with \> 2 pancreatic cancers in close relatives and aged \>50 or * Chronic pancreatitis and aged \>50 or carriers of PRSS1 or SPINK1 germline (P) or (LP) variants or * Patients at increased risk of pancreatic cancer based on a composite score or * Carriers of CDKN2A germline (P) or (LP) variants or * Carriers of germine (P) or (LP) variants in BRCA2, ATM, BRCA1, PALB2, or Lynch syndrome-associated gene alterations with a first-degree or multiple family history of pancreatic ductal carcinoma (PDAC) or * Patients with a Peutz-Jeghers syndrome (STK11 germline (P) or (LP) variants) or 7. Situations at increased risk of lung cancer \- History of heavy smoking \> 20 pack-years among active or previous smokers who have quitted up to 10 years ago, and aged ≥ 50 years, or 8. Situations at increased risk of skin cancers except basal-cell carcinomas * Carriers of germline (P) or (LP) variants in CDKN2A/CDK4 or BAP1 genes, aged ≥ 50 years or * Carriers of germline (P) or (LP) variants of genes that predispose to skin cancers (Xeroderma pigmentosum, etc…) or 9. Situations at increased risk of head and neck cancers * Individuals with high-grade dysplasia or carcinoma in situ of the upper aero digestive tract within the last 10 years, and aged ≥ 50 years, or * Individuals with oral lichen planus diagnosed more than 10 years ago, and aged ≥ 50 years or * Previous history of a head and neck cancer in complete remission for ≥ 5 years, aged ≥ 50 years, and at least one of the following criteria: Current or former smoker \> 10 pack-years Current or former alcohol consumption \> 14 units/week 10. Situations at increased risk of mesothelioma \- Individuals with a history of relevant professional exposure to asbestos, and/or germline (P) or (LP) variants in BAP1, and aged ≥ 50 years, or 11. Situations at increased risk of kidney cancer \- Carriers of germline (P) or (LP) variants in the BAP1, VHL, FH, cMET, FLCN, SDH-B genes, and aged ≥ 50 years, or 12. Situations at increased risk of prostate cancer * Men aged ≥ 40 year with any of the following: * Strong family history: a first- or second-degree relative with metastatic prostate cancer, ovarian cancer, male breast cancer, female breast cancer aged ≤ 45 years, colorectal or endometrial cancer aged ≤ 50 years, pancreatic cancer or two or more first- or second-degree relatives with breast, prostate (but not clinically localized grade group 1), colorectal or endometrial cancer at any age, or * Carriers of germline (P) or (LP) variants in BRCA1, BRCA2, ATM, HOXB13, hMLH1, MSH2, hMLH6, and PMS2, and aged \> 45 13. Situations at increased risk of urothelial cancers * History of heavy smoking \> 30 pack-years,