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40 Hz Visual Stimulation as an Intervention in Schizophrenia

RecruitingNAAges 18 Years - anyAllTechnical University of Munich
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In plain words

What the trial is, and whether it could suit you

In schizophrenia, an abnormal reduction in neuronal gamma oscillations (30-100 Hz) is associated with negative symptoms such as cognitive dysfunction. The literature suggests that rescuing gamma oscillations through non-invasive brain stimulation may be an accessible and safe add-on strategy to mitigate negative symptoms. Here, a stimulation protocol based on gamma visual stimulation will be tested. This pilot study will follow an uncontrolled clinical trial design: A minimum of ten patients diagnosed with schizophrenia or a schizoaffective disorder and predominant negative symptoms will be recruited at Klinikum rechts der Isar. They will undergo a multisession stimulation protocol, consisting of one hour of 40 Hz visual stimulation per day over five consecutive days, during which they will be encouraged to fall asleep. An equal number of patients will be recruited for a treatment-as-usu

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Medical diagnosis of schizophrenia (F20) or schizoaffective disorder (F25) Exclusion Criteria: * Age \< 18 years * Any history of seizures * Acute suicidality assessed with the Columbia-Suicide Severity Rating Scale (C-SSRS; Brent et al., 2008) * Any other relevant axis 1 disorder * Red-green colour blindness or current ocular disease * Alcohol, cannabis, or illicit drug addiction within the last 3 months
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What it tests

  • Visual stimulation
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Where

1 site
Technical University of Munich, TUM School of Medicine and Health, Department of Psychiatry and Psychotherapy
Munich, Germany
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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