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Efficacy and Safety of Citrate Anticoagulation in CRRT for Patients With Liver Failure/DysfuncTION, the CAUTION Trial! A Retrospective Study on Etiology of Liver Failure and Their Complications

Recruitingn/aAges 18 Years - anyAllUniversity Hospital, Antwerp
NCT06908746 on ClinicalTrials.gov โ†—
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In plain words

What the trial is, and whether it could suit you

Study design A retrospective cohort study will be conducted to compare the efficacy and safety of citrate anticoagulation in CRRT among patients with liver failure/dysfunction and severe shock. Objectives 1. Primary Objective: To determine if the etiology of liver failure impacts the incidence of citrate-related complications in patients undergoing CRRT. 2. Secondary Objectives: To compare the efficacy of citrate anticoagulation in terms of renal recovery, filter lifespan, and patient survival between those with liver failure/dysfunction and severe shock.

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Critically ill patients diagnosed with AKI requiring CRRT. Caution Protocol V1.0 24-07-2024 * Documented liver failure or significant liver dysfunction (e.g., elevated liver enzymes, bilirubin levels, or clinical diagnosis of liver failure) and clincal diagnosis of shock (NE of 0.25 ฮผg/kg/min and or association of second vasopressor). * Age โ‰ฅ 18 years. Exclusion Criteria: * NA
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What it tests

  • Not listed
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Where

1 site
Antwerp University Hospital
Edegem, Belgium
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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