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Multimodal Electrophysiological Study of Cortico-subcortical Biomarkers of Tics in Tourette Syndrome

RecruitingNAAges 16 Years - anyAllUniversity Hospital, Bordeaux
NCT06909656 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Tourette syndrome (TS) is a complex neurodevelopmental disorder characterized by the occurrence of involuntary movements (motor tics) and vocalizations (phonic tics). The onset of TS is usually in childhood, and the prevalence of TS is estimated between 0.3 and 0.9% before the age of 18, decreasing progressively after that age. Most patients also suffer from associated psychiatric comorbidities (ADHD, OCD, mood disorders). Although the cause of TS remains unknown, the preferred hypothesis is the interaction of predisposing genetic factors and precipitating environmental factors (perinatal accidents, infectious diseases). From a pathophysiological point of view, it is widely demonstrated by structural, electrophysiological studies, functional neuroimaging, as well as by different animal models, that dysfunctions of the cortico-striato-pallido-thalamo-cortical loops (responsible for the re

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patient at least 16 years old. * Disabling and drug-resistant Tourette's syndrome. * Receiving deep brain stimulation treatment with implantation of the PERCEPT™ Device as part of their medical management. * Normal brain MRI. * Subject affiliated or beneficiary of a social security system. * Free and informed consent of the patient and, for minors, of the minor and at least one parental authority. Exclusion Criteria: * Major depressive syndrome (Beck Depression Inventory (BDI-II) \> 20). * MRI showing significant brain atrophy or significant hyperintensities. * Pregnant or nursing mothers. * Person unable to give personal consent. * Person subject to a legal protection measure (curatorship, guardianship) or placed under court protection. * Patient included in another research protocol with an interdiction of participation to another research or in an exclusion period
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What it tests

  • Multimodal electrophysiological recordings
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Where

1 site
CHU de Bordeaux
Bordeaux, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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