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Whole-Brain Dynamics in the Natural Menstrual Cycle vs. an Ovarian Stimulated Cycle: Impact of Hormonal Fluctuations on Healthy Women Undergoing Ovarian Stimulation

Recruitingn/aAges 25 Years - 35 YearsFemaleART Fertility Clinics LLC
NCT06910293 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The investigators aim is to investigate the brain's dynamic complexity across three phases of an ovarian stimulation cycle (basal, pre-OPU, mid-luteal), to observe the impact of externally administered hormones, and compare it with the corresponding phases of a natural menstrual cycle (early follicular, pre-ovulatory, mid-luteal) in the same woman. Brain activity patterns will be examined using resting-state fMRI in a sample of young, healthy, naturally cycling women.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age group: 25 - 35 years old * BMI: 20 - 30 * Anti-Mullerian Hormone (AMH): 1.3 - 5.9 ng/ml * Regular Menstrual Cycle: 26-35 days * In case of previous use of hormonal contraception: wash-out period of 3 month * Meet standard safety and eligibility criteria for MRI scanning, including the absence of contraindications such as metallic implants, claustrophobia, or other medical conditions that preclude MRI Exclusion Criteria: * History of ovarian surgery * Pathology of the ovaries * Mental health disorders * Use of medication influencing brain function * Ongoing use of hormonal contraception (this would include OCP, but also patches and Mirena containing IUD)
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What it tests

  • Functional Magnetic resonance imaging will be done on day 2 or 3 of the menstrual cycle, trigger-shot and egg retrieval.
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Where

2 sites
ART Fertility Clinics LLC
Abu Dhabi, United Arab Emirates
ART Fertility Clinics LLC
Abu Dhabi, United Arab Emirates
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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