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Study of the Plasma and Urinary cfDNA of in Kidney Transplant Patients

Recruitingn/aAges 18 Years - anyAllPoulet Geoffroy
NCT06910527 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

It has been shown that the amount of circulating donor-cell-free DNA increases in patients with transplant rejection. Quantification of single nucleotide polymorphisms (SNPs) present in circulating donor DNA currently allows for early identification of transplant rejection, but not for characterization, i.e., identification of the affected renal fraction of the graft. Recently, in healthy subjects, teams have shown that it is possible to identify the tissue origin of donor-cell-free DNA, based on the epigenetic properties of circulating DNA. CGenetix is a MedTech company developing an in vitro diagnostic medical device to identify and quantify kidney graft degradation during transplant rejection. The objective of this study is to evaluate the sensitivity of the proposed technology to detect circulating renal DNA released into the blood and urine in kidney transplant patients with or wi

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients living with a kidney transplant * Admitted for suspected transplant rejection requiring a renal biopsy (RBB) as an indication Exclusion Criteria: * Patients with cognitive and mental disorders rendering them unable to express their non-opposition to participation in the study * Not covered by a social security system. * Under guardianship or guardianship, or under legal protection. * Patients who have expressed their refusal to participate in the study
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What it tests

  • Not listed
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Where

1 site
Chu Rouen-Bois Guillaume
Rouen, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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