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Hemodynamic Evaluation Using Microcirculation for Early Treatment of Septic Patients

RecruitingNAAges 18 Years - anyAllUniversity Hospital, Limoges
NCT06910891 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Despite early treatment, the deterioration and mortality of sepsis patients remains high. A possible explanation could be persistent tissue hypoperfusion, or undetected in the early phase despite the normalization of macro-hemodynamic parameters. This interventional study evaluates the impact of measuring microcirculation parameters by nurses on patient prognosis through early initiation of vascular filling.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Age ≥ 18 years 2. Admitted to the Emergency Department for suspected Sepsis for less than 6 hours according to international Sepsis-3 definitions (high probability of infection defined by a fever greater than or equal tol to 38.3°C with a suspected infectious source + Score NEWS 2 greater than or equal to 2) 3. Affiliated to a social security system 4. Having agreed to participate in this study Exclusion Criteria: 1. Patient with arterial hypotension (SBP ≤ 100 mmHg) on admission 2. Patient having already received a 500mL filling test over 30 minutes 3. Patients moribund according to the investigator 4. Pregnancy or breastfeeding 5. Patient under guardianship, curatorship or safeguard of justice
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What it tests

  • measurement of the peripheral perfusion index and marbling assessment
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Where

6 sites
Brive Hospital
Brivé, France
Guéret Hospital
Guéret, France
Limoges University Hospital
Limoges, France
Saint Junien Hospital
Saint-Junien, France
Tulle Hospital
Tulle, France
Ussel Hospital
Ussel, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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