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Neurophysiology of Locomotor Adaptation and Freezing of Gait in Parkinson's Disease

RecruitingNAAges 18 Years - 80 YearsAllUniversity of Florida
NCT06911229 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Locomotor adaptation will be studied using an established split-belt treadmill paradigm, consisting of baseline (1:1 speed ratio), split-belt adaptation (2:1) and post-adaptation (1:1) walking. Split-belt walking will be performed under DBS ON and DBS OFF conditions, while off-medication.

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📋 Eligibility rules (as published)
Inclusion Criteria: * consensus diagnosis of idiopathic PD by fellowship trained movement disorders neurologists at the Normal Fixel Institute of Neurological Diseases; * chronically stable DBS, defined as having had DBS for at least 6 months in duration with optimized DBS settings; * Age between 18 - 80 years old per the FDA data sheet for PD DBS; * no dementia according to the clinical diagnostic criteria for PD dementia; * ambulatory without the use of walking aids, or another person's assistance. Exclusion Criteria: * other previous neurological surgery; * suspicion of other neurologic diagnoses such as atypical parkinsonism, or Alzheimer's disease.
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What it tests

  • Deep Brain Stimulation (DBS)
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Where

1 site
University of Florida
Gainesville, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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