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Impact of Nutritional Management on the Frailty of Patients Waiting for Liver Transplantation (Via the LFI Tool)

RecruitingNAAges 18 Years - anyAllHospices Civils de Lyon
NCT06911619 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Cirrhosis is a major public health issue responsible for about 15000 deaths each year. Liver transplantation (LT) remains the only curative treatment for decompensated cirrhosis. Decompensated cirrhotic patients awaiting LT are malnourished, sarcopenic and fragile. The evaluation of the nutritional status of these patients is complex because the anthropometric data that define undernutrition (weight variation, BMI) are often compromised by the presence of edema and ascites related to liver disease. It therefore seems appropriate to focus on the fragility and sarcopenia of the cirrhotic patient as a reflection of the nutritional status. In 2017, the American team of Lai et al. validated a Liver fraily index (LFI) score of frailty specific to cirrhotic patients waiting for LT. The LFI is composed of three simple physical tests (Grip test, chair lift test, and balance tests) performed at th

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patient aged ≥ 18 years * Patient registered on the waiting list for Hepatic Transplantation in the Transplantation center of the Croix Rousse Hospital (GHN), Hospices Civils de Lyon * Dated and signed an informed consent * Affiliated to a social security scheme or beneficiary of a similar scheme Exclusion Criteria: * Patient hospitalized in intensive care * Patient with initial LFI test result \< to 3.2, that is considered as "robust". * Patient unable to perform LFI exercises (chronic or acute motor disability in lower or upper limbs) * Pregnant, parturient or lactating women * Persons deprived of liberty by a judicial or administrative decision * Persons under psychiatric care * Persons admitted to a health or social institution for purposes other than research * Adults subject to a legal protection measure (guardianship, curatorship) * Inability to understand protocol information * Subject participating in another interventional research including an ongoing exclusion period at inclusion
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What it tests

  • Dietary management
  • No dietary management
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Where

1 site
Hôpital de la Croix Rousse / GHN
Lyon, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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