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Impact of Aerobic Exercise on the Anticancer Immune Response in Patients Receiving Cancer Treatment

RecruitingNAAges 40 Years - 70 YearsAllUniversité de Sherbrooke
NCT06911970 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to determine to what extent anticancer immune cells mobilized by aerobic exercise exhibit migratory and functional capacity towards cancer cells in patients undergoing treatment for breast or colorectal cancer. The main questions it aims to answer are: • Do anticancer immune cells mobilized by aerobic exercise will display migratory and functional capacity in patients undergoing treatment for curable breast or colorectal cancer? Hypothesis: exercise will promote cell migration and these cells will display anti-cancer functional characteristics, suggesting a possible adjuvant and immunotherapeutic use of exercise. • Do the magnitude of this anti-cancer immune response to exercise depend on the intensity of exercise? Hypothesis: the achievement of a higher intensity of effort will enable greater mobilization of the cytotoxic lymphocytes of interest, b

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📋 Eligibility rules (as published)
Inclusion Criteria: * Diagnosis of non-metastatic breast or colon cancer * Age between 40 and 70 * Have started chemotherapy or immunotherapy treatment and have at least three treatments remaining in the cycle * ECOG stage 0 to 1 * Be able to perform moderate-intensity aerobic exercise (MOD) or EPI type cycling according to the established prescription and without experiencing pain in connection with the bicycle saddle Exclusion Criteria: * Orthopedic, cardiac or metabolic limitation preventing safe aerobic exercise * Non-controlled health condition * Use of beta-blockers * Planned surgery during the study period.
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What it tests

  • Exercise
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Where

2 sites
Research Center on Aging
Sherbrooke, Canada
Research Center on Aging
Sherbrooke, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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