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Bilateral Single-Electrode VO Combined With STN-DBS for Treating Meige Syndrome

RecruitingNAAges 18 Years - anyAllHuashan Hospital
NCT06912282 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Meige syndrome is a rare and debilitating movement disorder characterized by blepharospasm, oromandibular dystonia, and cervical muscle contractions, often refractory to pharmacological therapies. Deep brain stimulation (DBS), initially developed to treat essential tremor and Parkinson's disease, has been explored in recent years as a potential treatment for various dystonias, including Meige's syndrome. This clinical study aims to evaluate the safety and efficacy of bilateral single-electrode ventralis oralis (VO) nucleus stimulation combined with subthalamic nucleus deep brain stimulation (STN-DBS) in patients with Meige syndrome.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Must meet the clinical diagnostic criteria for Meige syndrome * Only includes patients with: Blepharospasm-type Meige syndrome and Blepharospasm with lower jaw muscle dystonia-type * All patients must have undergone at least one year of systematic and standard treatment prior to surgery Exclusion Criteria: * History of neurological diseases other than Meige syndrome * Severe cognitive impairment * Severe psychiatric disorders
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What it tests

  • deep brain stimulation
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Where

1 site
Huashan Hospital, Fudan University.
Shanghai, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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