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Modulation of the Inflammatory Response in Bariatric Surgery

Recruitingn/aAges 18 Years - 65 YearsAllHospital HM Nou Delfos
NCT06915558 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study will evaluate how different anesthesia techniques affect inflammation after bariatric surgery. Patients will be randomly assigned to receive one of three approaches: opioid-free anesthesia, intravenous anesthesia with opioids, or inhalational anesthesia with opioids. The study will measure blood levels of inflammation-related substances (such as IL-6, CRP, cortisol, ESR , WBC and lactate) at several time points before and after surgery. Heart rate variability will also be monitored as an indicator of the body's stress response. The results may help identify anesthesia strategies that reduce inflammation and improve recovery in patients undergoing bariatric surgery.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients scheduled for bariatric surgery. * Age 18-65 years. * BMI ≥ 30 kg/m². * ASA physical status II-III. Exclusion Criteria: * Pregnancy or breastfeeding. * Chronic opioid use before surgery. * Severe renal or hepatic failure. * Uncontrolled psychiatric disorders. * Significant intraoperative complications requiring protocol deviation.
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What it tests

  • Opioid-Free Anesthesia (OFA)
  • Opioid-Based Intravenous Anesthesia (OBA-IV)
  • Opioid-Based Inhalational Anesthesia (OBA-Inh)
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Where

1 site
Hospital HM Nou Delfos
Barcelona, Spain
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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