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Study of the Effect of Capsinoid Supplementation on Brown Adipose Tissue in Obese Adolescents

RecruitingNAAges 11 Years - 18 YearsAllUniversity of Avignon
NCT06916208 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Among the new strategies being considered for the treatment of obesity and its metabolic complications, the activation of brown adipose tissue (BAT) from white adipose tissue looks promising. Interest in the study of BAT has increased over the last 5-10 years in response to the discovery of functional BAT in humans. The BAT is a tissue specialized in regulating energy expenditure by producing heat through the oxidation of fatty acids contained in the multiple lipid droplets of brown adipocytes. This adipose tissue does not play a storage role, but rather an anti-obesogenic one, thanks to its high metabolic and energetic activity. In addition to exposure to cold, which is the major physiological inducer of brown adipocytes, it seems that exercise and the intake of "adrenergic" foods can activate the TAB and potentially induce a change from white to brown tissue via the production of adre

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📋 Eligibility rules (as published)
Inclusion Criteria: * member or beneficiary of a health insurance scheme * aged between 11 and 18 * Body Mass Index Z score corresponding to stage 2 obesity according to the curves of Rolland-Cachera et al., 1991 and an absence of weight loss of more than 5% of the total weight over the last 3 months. * effective contraception (in pubescent females) Exclusion Criteria: * known allergy to capsinoids and/or soya * inflammatory digestive pathology and/or history of digestive tract surgery * participation in another study or in a period of exclusion determined by a previous study * pregnant, parturient or breastfeeding * The holder(s) of parental authority or the adolescent refuse(s) to sign the authorisation or acceptance form, respectively. * It proves impossible to provide the adolescent or parental guardian(s) with informed information.
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What it tests

  • capsinoid supplementation
  • Control group (placebo)
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Where

1 site
Institut Saint Pierre
Palavas-les-Flots, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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