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A Study of Efimosfermin Alfa in Participants With Biopsy-confirmed Cirrhosis (Compensated) Due to MASH

RecruitingPhase 2Ages 18 Years - 75 YearsAllGlaxoSmithKline
NCT06920043 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The purpose of this study is to evaluate the safety, tolerability, preliminary efficacy, and pharmacokinetics (PK) of efimosfermin in participants with metabolic dysfunction associated steatohepatitis (MASH) and compensated cirrhosis consistent with stage F4 fibrosis.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Ability to understand and sign a written informed consent form (ICF) * Age 18 through 75 years at enrollment * History or presence of 2 or more of the 5 components of metabolic syndrome * Liver biopsy confirmation of MASH consistent with stage F4 fibrosis * Other inclusion criteria may apply. Exclusion Criteria: * Individuals with chronic liver disease from other causes, or any history or evidence of decompensated liver disease * History of type 1 diabetes * Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) ≥5 × the upper limit of normal (ULN) * Other exclusion criteria may apply.
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What it tests

  • Efimosfermin
  • Placebo
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Where

30 sites
GSK Investigational Site
Chandler, United States
GSK Investigational Site
Mesa, United States
GSK Investigational Site
Tucson, United States
GSK Investigational Site
Fresno, United States
GSK Investigational Site
Lancaster, United States
GSK Investigational Site
Pasadena, United States
GSK Investigational Site
Rialto, United States
GSK Investigational Site
Santa Maria, United States

…and 22 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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