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โ† Trials
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POCUS-Guided Diuresis for Decompensated Heart Failure

RecruitingNAAges 18 Years - anyAllUniversity of Pittsburgh
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In plain words

What the trial is, and whether it could suit you

Heart failure occurs when the heart cannot pump blood effectively, leading to fluid buildup in the body. This can cause problems such as difficulty breathing, swelling, and extreme tiredness. In severe cases, these symptoms worsen to the point where hospitalization is required. Unfortunately, many patients with severe heart failure are readmitted to the hospital within 30 days after discharge, which is both physically and emotionally challenging for patients and places a significant financial burden on individuals and the healthcare system. Although symptoms such as difficulty breathing and swelling may improve during the hospital stay, some patients are discharged with excess fluid remaining in their bodies. This retained fluid often causes symptoms to worsen, leading to subsequent hospital readmissions. Inadequate management of fluid levels can also harm the kidneys, further complicat

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
List the inclusion criteria: 1. Age: Patients must be 18 years or older. 2. Diagnosis: Must have a confirmed diagnosis of acute decompensated heart failure (ADHF). 3. Treatment Plan: Patients must be planned for treatment with intravenous (IV) diuretics. 4. POCUS Measurement: Must have an abnormal right internal jugular vein (RIJV) distensibility index (DI) of \<66% on point-of-care ultrasound (POCUS) at the time of admission. These criteria ensure that participants are appropriately selected for the study and are likely to benefit from POCUS-guided diuretic management. List the exclusion criteria: 1. Left Ventricular Assist Devices (LVAD): Patients with LVADs will be excluded due to their unique hemodynamics, which may interfere with study assessments. 2. Anatomical Incompatibilities: Excludes patients with RIJV or superior vena cava thrombus, congenital heart disease, or severe tricuspid regurgitation, as these conditions may impair accurate POCUS measurements. 3. Cardiomyopathy: Patients with hypertrophic or infiltrative cardiomyopathy will be excluded. 4. End-of-Life Care: Patients receiving hospice care or comfort measures only will not be included in the study. 5. Advanced Cancer: Patients with metastatic cancer will be excluded. 6. Severe Liver Dysfunction: Patients with a MELD-Na score greater than 20, indicating severe liver dysfunction, will be excluded. 7. End stage chronic kidney disease 8. Inability to Provide Consent: Patients who are unable to provide informed consent, due to cognitive impairment or other reasons, will not be eligible. 9. Inotropic Support: Patients requiring inotropic support at the time of enrollment will be excluded, as they represent a more severe heart failure profile that may not be suitable for this trial.
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What it tests

  • Furosemide (Standard Diuretic) Treatment
  • POCUS-Assessed Diuretic Management
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Where

5 sites
UPMC East
Pittsburgh, United States
University of Pittsburgh Medical Center
Pittsburgh, United States
UPMC Presbyterian
Pittsburgh, United States
UPMC Mercy
Pittsburgh, United States
UPMC Shadyside
Pittsburgh, United States
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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