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Changes in the Urinary Microbiome and Metabolome During Treatment of the Overactive Bladder in Female Patients

Recruitingn/aAges 18 Years - anyFemaleUniversity Hospital Ostrava
NCT06921746 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This is a non-interventional study that will not pose any burden for the participants. The study subjects will be examined and treated in a standard manner according to current clinical recommendations for the treatment of overactive bladder (OAB). A portion of urine samples, which are routinely collected for biochemical and culture examinations as part of the diagnostic process, will be sent for examination of the characteristics of the urinary microbiome and metabolome (UMM) before and after treatment.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adult women over 18 years of age * Written consent to participate in the study * Willingness to undergo OAB evaluation and treatment according to the protocol * OAB symptoms lasting longer than 3 months * At least 3 episodes of severe urgency with or without urge incontinence within 3 days documented by voiding diary * OAB symptom score V8 questionnaire ≥ 8 Exclusion Criteria: * Known congenital developmental defects of the urinary tract (congenital hydronephrosis, vesicoureteral reflux, renal agenesis and hypoplasia, multicystic and polycystic kidneys) * Any previous treatment for OAB * Recurrent urinary tract infections (more than 3 episodes in the last 12 months) * Presence of a foreign body in the urinary tract - urolithiasis, urinary catheter, ureteral stent * Acute or chronic diseases with possible influence on the function of the lower urinary tract (LUT) * Rheumatoid arthritis * Diabetes mellitus
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What it tests

  • Urine Microbiological and Metabolomic Analysis
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Where

4 sites
University Hospital Ostrava
Ostrava, Czechia
Thomayer University Hospital
Prague, Czechia
Institute of Microbiology of the Czech Academy of Sciences
Prague, Czechia
University Hospital Bulovka
Prague, Czechia
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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