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โ† Trials
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Lung Ultrasound for Guiding Antibiotic Use in Pediatric Pneumonia

RecruitingNAAges 3 Years - 10 YearsAllMeyer Children's Hospital IRCCS
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In plain words

What the trial is, and whether it could suit you

Pneumonia is a major cause of illness and death in children, with an annual incidence of about 3.3 per 1,000 in those under five years old, many requiring hospitalization. The diagnosis is challenging due to the absence of a universally accepted gold standard, leading to variability in emergency settings. Current guidelines recommend diagnosis based on history and physical examination, which do not reliably differentiate pneumonia from other respiratory infections or identify whether it is bacterial or viral in nature. This uncertainty can lead to the unnecessary use of antibiotics. Commonly used chest X-rays have limitations such as low sensitivity, moderate interobserver reliability, and the inability to distinguish bacterial from viral pneumonia. In contrast, lung ultrasound has shown high sensitivity and specificity for diagnosing pneumonia in children. However, lung ultrasound also

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Well-appearing, clinically stable patients aged 3 to 10 years, presenting to the pediatric ED with suspected pneumonia based on a combination of signs and symptoms suggestive of lower respiratory tract infection (LRTI), including: 1. Respiratory Symptoms: Cough, Tachypnea, Dyspnea (Increased work of breathing), Abnormal findings on auscultation. 2. Systemic Symptoms: Fever, Hypoxia, Decreased appetite. Exclusion Criteria: * Neonates and children up to 3 years of age, and children older than 10 years * Children aged 3 to 10 years with any of the following factors: 1. Recent hospitalization (within the past 14 days) 2. Prior CXR or any other chest imaging (e.g. CT scan) 3. Ongoing antibiotic therapy 4. Hemodynamic instability 5. Respiratory failure or severe respiratory distress and/or hypoxemia, requiring urgent assessment for conditions such as pneumothorax, hemothorax, or other emergency respiratory conditions 6. History of aspiration or ab ingestis pneumonia 7. Underlying medical conditions predisposing to severe or recurrent pneumonia, including immunodeficiency, chronic corticosteroid use, chronic lung disease, malignancy, sickle cell disease, congenital heart disease, tracheostomy, and neuromuscular disorders affecting respiration
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What it tests

  • LUNG ULTRASOUND
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Where

18 sites
Rady Childrens/UCSD
San Diego, United States
Yale New Haven Children's Hospital
New Haven, United States
Columbia University
New York, United States
University of Wisconsin
Madison, United States
Schneider Children's Hospital
Petah Tikva, Israel
Meyer Children's Hospital IRCCS
Florence, Italy
ASST Papa Giovanni XXIII
Bergamo, Italy
IRCCS Sant'Orsola
Bologna, Italy

โ€ฆand 10 more on ClinicalTrials.gov.

๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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