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De-stressing the Brain: Can Eating Grapes During Periods of Mental Stress Protect Brain and Vascular Health in Young Adults

RecruitingNAAges 18 Years - 40 YearsAllUniversity of Birmingham
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In plain words

What the trial is, and whether it could suit you

The main aim of the current study is to investigate whether consuming grapes rich in flavonoids just before mental stress can protect cerebrovascular and peripheral vascular function, mood and cognition, from the negative effects of mental stress in young healthy adults. A second, exploratory aim, will further address whether quality of habitual diet, microbiome health (composition; metabolites production e.g. Short-chain fatty acids) and levels of cardiorespiratory fitness play a role on the beneficial effects of grapes during mental stress. All participants will receive a high-flavonoid grape intervention (60 g freeze-dried grape powder, equivalent to 300 g fresh grapes) and a low-flavonoid grape intervention (60 g powdere isocaloric-matched control). It is hypothesized that the high-flavonoid grape intervention will improve cortical oxygenation and cognitive function in the context of

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Males and females * 18 - 40 years old Exclusion Criteria: * Smokers * Consumes \> 21 units of alcohol per week * History of cardiovascular, respiratory, metabolic, liver or inflammatory diseases * Suffers from blood-clotting disorders * Allergies or intolerances to foods * On a weight reducing dietary regiment * Currently taking dietary supplements, including fatty acids and vitamins * On long-term medication or have been on antibiotics in the last 3 months * Has an infection at present (e.g. cold) or viral infection
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What it tests

  • High-flavonoid grape intervention
  • Low-flavonoid grape intervention
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Where

1 site
School of Sport, Exercise & Rehabilitation Sciences
Birmingham, United Kingdom
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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