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Comparison of Skin Prick Testing, Extract-specific IgE Antibody Testing and Component Resolved Diagnosis in Diagnosing of Legume Allergy

Recruitingn/aAges 4 Months - 65 YearsAllUniversity Hospital Pilsen
NCT06923878 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The study is aimed at improving the diagnosis of food allergy, specifically allergy to commonly consumed legumes such as peas, lentils, chickpeas or green beans. Patients suspected of allergy to these legumes will be examined using traditional methods of IgE-mediated allergy diagnosing (skin prick test, testing for specific IgE antibodies against food extract), but also by testing for specific IgE antibodies against relevant allergenic molecules of these legumes. The results of performed tests will be compared with the result of the oral food challenge, which is considered to be the gold standard of food allergy diagnosis.

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📋 Eligibility rules (as published)
Inclusion Criteria: * age: ≤ 65 years * signing informed consent to the study * a positive history of an immediate allergic reaction to one or more of the legumes studied (peas, lentils, chickpeas, beans) with skin, gastrointestinal, respiratory or cardiovascular symptoms occurring within 2 hours after ingestion and a positive result of specific IgE testing against ALEX and/or skin prick test with the legume * patients with a positive OFC with any of the legumes studied Exclusion Criteria: * disagreement with the implementation of the oral food challenge * history of severe systemic allergic reaction to the legume in question (Ring-Messmer grade ≥ 3)
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What it tests

  • Not listed
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Where

1 site
University Hospital Pilsen
Pilsen, Czechia
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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