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Stereotactic Body Radiotherapy or Standard of Care for Prostate Oligoprogressive Cancer

RecruitingPhase 2Ages 18 Years - 100 YearsMaleUniversity Health Network, Toronto
NCT06927635 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This is a single centre, interventional, randomized Phase II, two-arm prospective trial investigating if Stereotactic Body Radiotherapy (SBRT) to all sites of Oligopressive (OP) disease while remaining on current Systemic Therapy (ST) will improve biochemical control compared to Standard of Care (SoC) (which involves a change in ST) for patients with OP Castrate Resistance Prostate Cancer (CRPC).

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age \>18 years * Able to provide informed consent * Histologic diagnosis of prostate adenocarcinoma * Castrate Resistance Prostate Cancer * Radiographic evidence of \<10 sites of extra-cranial OP metastatic lesions * Receiving any line of ST for \>3 months * All sites of OP disease are amenable to and can be safely treated with SBRT * ECOG performance status 0-3 Exclusion Criteria: * Evidence of spinal cord compression * Contraindication to radiotherapy
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What it tests

  • Stereotactic Body Radiation Therapy (SBRT)
  • Systemic therapy
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Where

1 site
Princess Margaret Cancer Center
Toronto, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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